fadR [2017-02-27 15:02:04]

transcriptional repressor (TetR family), regulation of fatty acid degradation

locus: BSU28550

pI: 6.12

mw: 21.00 kDa

protein length: 194 aa

gene length: 582 bp

function: regulation of fatty acid degradation

product: transcriptional repressor

essential: no

synonyms: ysiA

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.1|Utilization of lipids] → [category|SW 2.4.1.3|Utilization of fatty acids]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]

This gene is a member of the following [SW|regulons]

• [SW|CcpA regulon], [SW|FadR regulon]

Gene

Coordinates on the chromosome (coding sequence): 2,917,957 -> 2,918,541

The protein

Protein family

• [SW|TetR family]

Effectors of protein activity

• long chain fatty acids act as inducers that release FadR from its operator sites [Pubmed|24356978]

Expression and Regulation: [[this]]

Biological materials

Mutant

• MGNA-B008 (ysiA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1007 NBRP B. subtilis, Japan]
• 1A853 ( ''fadR''::''cat''), [Pubmed|17085570], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A853&Search=1A853 BGSC]

References

Reviews

• 17919287,24006471

Original publications

• 17189250,21398533,24356978